Description

1-(5-Nitrothiophene-2-Carbonyl)Piperazine Hydrochloride is a high-purity, synthetically valuable chemical building block primarily used in pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting complex disease pathways. It is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry research.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development stages for creating new therapeutic agents.
• Biochemical Research: Employed as a reagent or precursor in the study of biological pathways and target validation.
• Fine Chemical Synthesis: Serves as a specialized intermediate for constructing complex organic molecules with potential biological activity.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations engaged in custom synthesis and scale-up of pharmaceutical compounds.

Basic Information

Product Name	1-(5-Nitrothiophene-2-Carbonyl)Piperazine Hydrochloride
CAS No.	1171194-70-9
Molecular Formula	C10H12N4O3S • HCl
Molecular Weight	304.75 g/mol (Free base: 268.29 g/mol)
Synonyms	1-(5-Nitro-2-thienylcarbonyl)piperazine hydrochloride; 1-(5-Nitrothiophene-2-carbonyl)piperazine monohydrochloride; Piperazine, 1-(5-nitro-2-thienylcarbonyl)-, hydrochloride (1:1); 5-Nitro-2-thiophenecarboxylic acid piperazide hydrochloride; 1171194-70-9; (5-Nitrothiophene-2-carbonyl)piperazine HCl
EINECS	Contact for details

Quality Control

Our 1-(5-Nitrothiophene-2-Carbonyl)Piperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (Titration)	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.