Description

2,3,4,5-Tetrahydro-7-Methoxy-4-(Methyl-D3)- CAS NO 1167435-22-4 is a high-purity, deuterated organic compound, specifically a methoxy-substituted tetrahydroisoquinoline derivative with a trideuterated methyl group. This compound is of significant value as a stable isotope-labeled intermediate or reference standard in advanced research and development. It is primarily needed by pharmaceutical, agrochemical, and analytical chemistry laboratories for applications in drug metabolism studies (DMPK), pharmacokinetic research, and as an internal standard for mass spectrometry.

Application

• Pharmaceutical Research & Development: Critical intermediate in the synthesis of deuterated drug candidates for improved metabolic stability and pharmacokinetic profiles.
• Metabolite Identification & DMPK Studies: Used as a stable isotope-labeled internal standard in LC-MS/MS for accurate quantification of parent drugs and their metabolites in biological matrices.
• Mechanistic Studies: Employed in tracer experiments to elucidate complex biochemical pathways and reaction mechanisms.
• Agrochemical Development: Potential building block for creating novel, labeled active ingredients or for environmental fate studies.
• Analytical Reference Standard: Serves as a certified reference material (CRM) for method development, validation, and quality control in analytical laboratories.
• Neuroscience Research: Investigated as a precursor or analog in the study of central nervous system (CNS) targets due to its tetrahydroisoquinoline scaffold.

Basic Information

Item	Details
Product Name	2,3,4,5-Tetrahydro-7-Methoxy-4-(Methyl-D3)- CAS NO 1167435-22-4
CAS No.	1167435-22-4
Molecular Formula	C11H14D3NO
Molecular Weight	182.27 g/mol (approx.)
Synonyms	4-(Methyl-d3)-1,2,3,4-tetrahydro-7-methoxyisoquinoline; 7-Methoxy-4-(trideuteriomethyl)-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-7-methoxy-4-(methyl-d3)isoquinoline; Deuterated THIQ derivative; 1167435-22-4; Tetrahydroisoquinoline-d3 derivative
EINECS	Contact for details

Quality Control

Every batch of 2,3,4,5-Tetrahydro-7-Methoxy-4-(Methyl-D3)- CAS NO 1167435-22-4 is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for research and development. A detailed Certificate of Analysis (COA), including results for purity (HPLC), isotopic enrichment (NMR/MS), and identity confirmation, is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C in a cool, dry place. The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.