Description

1-Boc-Indazole-5-Boronic Acid is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily utilized by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those containing indazole cores for oncology, CNS, and metabolic disease research.
• Suzuki-Miyaura Cross-Coupling: Enables the formation of carbon-carbon bonds to attach diverse aryl and heteroaryl groups to the indazole scaffold.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides requiring specific heterocyclic structures.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysts, and novel polymers.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Facilitates the modular assembly of bifunctional molecules for targeted protein degradation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring high-fidelity boronic acid reagents.

Basic Information

Product Name	1-Boc-Indazole-5-Boronic Acid
CAS No.	1167418-12-3
Molecular Formula	C₁₂H₁₅BN₂O₄
Molecular Weight	262.07 g/mol
Synonyms	5-Borono-1-[(tert-butoxy)carbonyl]-1H-indazole; 1H-Indazole-5-boronic acid, 1-[(1,1-dimethylethoxy)carbonyl]-; tert-Butyl 5-borono-1H-indazole-1-carboxylate; 1-Boc-5-indazoleboronic acid; 1-(tert-Butoxycarbonyl)-1H-indazole-5-boronic acid; 1-Boc-1H-indazole-5-boronic acid; BOC-Indazole-5-Boronic Acid
EINECS	Contact for details

Quality Control

Our 1-Boc-Indazole-5-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and process chemistry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.