Description

tert-Butyl 6-Cyano-5-Methyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its protected amine and cyano-substituted isoquinoline core structure. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization due to its functionalized isoquinoline ring system.
• API Development: Used in the development and scale-up processes for new Active Pharmaceutical Ingredients (APIs), particularly those requiring a dihydroisoquinoline pharmacophore.
• Chemical Biology Probes: Employed in the design and synthesis of chemical probes for investigating biological pathways and target validation.
• Custom Synthesis: A valuable starting material for contract research and manufacturing organizations (CROs/CMOs) performing bespoke synthesis for clients.

Basic Information

Product Name	tert-Butyl 6-Cyano-5-Methyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	1165923-92-1
Molecular Formula	C16H20N2O2
Molecular Weight	272.34 g/mol
Synonyms	2(1H)-Isoquinolinecarboxylic acid, 6-cyano-3,4-dihydro-5-methyl-, 1,1-dimethylethyl ester; 6-Cyano-5-methyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 6-cyano-5-methyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; Boc-6-cyano-5-methyl-1,2,3,4-tetrahydroisoquinoline; 1165923-92-1; 6-Cyano-5-methyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Cyano-5-Methyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.