Description

3-(3,5-Difluorobenzyl)Indolin-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its indolinone core with a difluorobenzyl substituent. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel bioactive molecules targeting various disease pathways. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially kinase inhibitors and other enzyme-targeting molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Chemical Biology Probes: Serves as a core scaffold for developing tool compounds to study biological pathways and target validation.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses requiring a functionalized indolinone moiety.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Product Name	3-(3,5-Difluorobenzyl)Indolin-2-One
CAS No.	1165901-72-3
Molecular Formula	C15H11F2NO
Molecular Weight	259.25 g/mol
Synonyms	3-[(3,5-Difluorophenyl)methyl]-1,3-dihydro-2H-indol-2-one; 3-(3,5-Difluorobenzyl)-2-indolinone; 2H-Indol-2-one, 3-[(3,5-difluorophenyl)methyl]-1,3-dihydro-; 3-(3,5-Difluorobenzyl)indolin-2-one; 1165901-72-3; 3-(3,5-Difluorobenzyl)-1,3-dihydro-2H-indol-2-one; 3-(3,5-Difluorobenzyl)-2-oxindole
EINECS	Contact for details

Quality Control

Our 3-(3,5-Difluorobenzyl)Indolin-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support our partners in the pharmaceutical supply chain with the documentation required for their regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.