Description

5-Benzyl-2-(3-Carboxy-Acryloylamino)-4-Methyl-Thiophene-3-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex thiophene-based molecular structure. This compound is critical for research and development in medicinal chemistry, serving as a key building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies in drug discovery programs.
• Organic Synthesis Reference Standard: Serves as a high-purity standard for analytical method development and validation in QC laboratories.
• Bioconjugation Chemistry: The reactive carboxylic acid and acryloylamino groups enable its use in creating targeted molecular probes or drug-linker systems.
• Academic & Institutional Research: Employed in university and government labs for fundamental research in heterocyclic and synthetic organic chemistry.

Basic Information

Product Name	5-Benzyl-2-(3-Carboxy-Acryloylamino)-4-Methyl-Thiophene-3-Carboxylic Acid Methyl Ester
CAS No.	1164481-94-0
Molecular Formula	C20H19NO5S
Molecular Weight	385.43 g/mol
Synonyms	Methyl 5-Benzyl-2-[(3-carboxyacryloyl)amino]-4-methylthiophene-3-carboxylate; 5-Benzyl-2-(3-Carboxyacryloylamino)-4-methylthiophene-3-carboxylic Acid Methyl Ester; 2-[(3-Carboxyacryloyl)amino]-5-benzyl-4-methylthiophene-3-carboxylic acid methyl ester; AKOS BRN-0793; 1164481-94-0; Thiophene-3-carboxylic acid derivative; Acrylamido-thiophene carboxylate ester.
EINECS	Contact for details

Quality Control

Our production of 5-Benzyl-2-(3-Carboxy-Acryloylamino)-4-Methyl-Thiophene-3-Carboxylic Acid Methyl Ester adheres to stringent quality management protocols. Each batch is analytically verified using advanced techniques like HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under inert atmosphere when not in use to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.