Description

3,4-Di(Methoxy-D3)Benzeneethanamine is a deuterated derivative of a key phenethylamine scaffold, where the methoxy groups are specifically labeled with deuterium (D3). This compound is of significant value for its use as a stable isotope-labeled internal standard in quantitative analytical methods, ensuring unparalleled accuracy and reliability in measurement. It is primarily required by research and development laboratories in the pharmaceutical, agrochemical, and analytical chemistry sectors for applications in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and environmental fate analysis.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the precise quantification of its non-deuterated analogs or related metabolites in complex biological matrices.
• Drug Metabolism Studies (DMPK): Used in pharmaceutical R&D to track the absorption, distribution, metabolism, and excretion (ADME) of drug candidates, leveraging deuterium's kinetic isotope effect for mechanistic insights.
• Bioanalytical Method Development: Essential for developing and validating robust, GLP-compliant analytical methods in clinical and preclinical trials to ensure data integrity.
• Environmental Analysis: Employed as a labeled surrogate standard in the analysis of environmental samples for trace-level detection of specific chemical pollutants or degradation products.
• Chemical Synthesis Intermediate: Acts as a specialized building block for the synthesis of more complex deuterated compounds for research purposes.
• Quality Control & Reference Material: Functions as a high-purity certified reference material (CRM) for calibrating instruments and verifying analytical procedures in quality control laboratories.

Basic Information

Product Name	3,4-Di(Methoxy-D3)Benzeneethanamine
CAS No.	1162658-07-2
Molecular Formula	C10H11D6NO2
Molecular Weight	185.27 g/mol
Synonyms	3,4-Bis(methoxy-d3)phenethylamine; 2-(3,4-Bis(methoxy-d3)phenyl)ethanamine; 3,4-Dimethoxy-d6-phenethylamine; Deuterated DMPEA; 3,4-Dimethoxyphenethylamine-d6; 3,4-(MeO-d3)2-PEA; 2-(3,4-Dimethoxyphenyl)ethan-1-amine-d6
EINECS	Contact for details

Quality Control

Our 3,4-Di(Methoxy-D3)Benzeneethanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C) and mass spectrometry for structural confirmation and isotopic purity assessment, and HPLC for chemical purity determination. We provide comprehensive Certificates of Analysis (COA) detailing batch-specific results for isotopic enrichment, chemical purity, and identity, ensuring compliance with research and analytical standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider sealing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D (per methoxy-d3 group)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.