Description

n-[(1R)-2'-Amino-3,3'-Dibromo-4,4',6,6'-Tetrakis(Trifluoromethyl)[1,1'-Biphenyl]-2-Yl]-P,p-Diphenyl-Phosphinous Amide is a sophisticated, high-value chiral organophosphorus compound featuring a unique biphenyl scaffold heavily substituted with bromine and trifluoromethyl groups. This complex structure makes it a critical intermediate or ligand for advanced synthetic chemistry, particularly in the development of pharmaceuticals and specialty materials where precise stereochemistry and electronic properties are paramount. It is primarily sought by R&D chemists and process development scientists in pharmaceutical, agrochemical, and advanced material sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block or ligand in the asymmetric synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) or oncology targets.
• Catalyst Ligand: Functions as a specialized phosphinous amide ligand in transition metal catalysis (e.g., palladium, rhodium) for cross-coupling, hydrogenation, or other asymmetric transformations.
• Agrochemical Research: Used in the discovery and synthesis of novel, high-performance crop protection agents with unique modes of action.
• Material Science Precursor: Acts as a monomer or functional additive in the development of advanced polymers, liquid crystals, or electronic materials leveraging its fluorinated aromatic system.
• Chemical Biology Probe: Employed in medicinal chemistry to study enzyme inhibition or receptor binding due to its potential for specific molecular interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific research and small-scale production projects.

Basic Information

Product Name	n-[(1R)-2'-Amino-3,3'-Dibromo-4,4',6,6'-Tetrakis(Trifluoromethyl)[1,1'-Biphenyl]-2-Yl]-P,p-Diphenyl-Phosphinous Amide
CAS No.	1161404-71-2
Molecular Formula	C26H13Br2F12N2P
Molecular Weight	~ 818.11 g/mol
Synonyms	(R)-N-(2'-Amino-3,3'-dibromo-4,4',6,6'-tetrakis(trifluoromethyl)-[1,1'-biphenyl]-2-yl)-P,P-diphenylphosphinous amide; (1R)-2'-Amino-3,3'-dibromo-4,4',6,6'-tetrakis(trifluoromethyl)-1,1'-biphenyl-2-yl-diphenylphosphinous amide; CAS 1161404-71-2; Biphenyl phosphinous amide derivative; Chiral biphenylphosphinous amide ligand; ATBPA ligand (abbrev.); Advanced trifluoromethylated ligand.
EINECS	Contact for details

Quality Control

Every batch of this high-purity specialty chemical is produced and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), chiral purity (≥98% ee), and impurity profiles. Our quality commitment aligns with cGMP and ISO 9001 principles for traceability and consistency, ensuring reliability for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is likely moisture-sensitive and should be handled under an inert atmosphere (argon/nitrogen) for long-term storage to maintain stability. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.