Description

n-(2-Hydroxyethyl)Piperazine-D4 is a deuterated analog of N-(2-Hydroxyethyl)piperazine, a versatile chemical building block where four hydrogen atoms are replaced with deuterium. This deuteration provides a stable isotopic label, making it a critical tool for advanced analytical and research applications where tracking molecular behavior is essential. It is primarily required by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors for use in metabolic studies, NMR spectroscopy, and as a precursor for labeled compounds.

Application

• As a deuterated internal standard for the precise quantification of its non-deuterated counterpart in analytical methods like LC-MS and GC-MS.
• In pharmaceutical research for drug metabolism and pharmacokinetics (DMPK) studies, enabling the tracing of molecular pathways.
• As a labeled building block in the synthesis of deuterated active pharmaceutical ingredients (APIs) or agrochemicals to alter metabolic profiles.
• For use in NMR spectroscopy as a solvent or reagent to simplify spectral analysis and avoid signal interference from protons.
• In academic and industrial R&D for mechanistic studies and as a tracer in chemical reaction pathways.
• As a specialty intermediate for producing other deuterium-labeled fine chemicals and complex molecules.

Basic Information

Product Name	n-(2-Hydroxyethyl)Piperazine-D4
CAS No.	1160357-16-3
Molecular Formula	C6H10D4N2O
Molecular Weight	134.22 g/mol
Synonyms	1-(2-Hydroxyethyl)piperazine-2,2,3,3-d4; N-(2-Hydroxyethyl)piperazine-d4; 2-(Piperazin-1-yl)ethanol-d4; HEP-d4; Deuterated HEP; N-Hydroxyethylpiperazine-d4; 1-Piperazineethanol-d4; 2-(1-Piperazinyl)ethanol-d4
EINECS	Contact for details

Quality Control

Our n-(2-Hydroxyethyl)Piperazine-D4 is produced under controlled conditions to ensure high isotopic and chemical purity, meeting the stringent requirements for research and development. Each batch is accompanied by comprehensive analytical data, including NMR and MS analysis to confirm deuteration level and chemical identity. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.