Description

tert-Butyl 7-Methoxy-3,4-Dihydro-2H-Spiro[Isoquinoline-1,4'-Piperidine]-1'-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic and heterocyclic architecture. This compound is critical for research and development in medicinal chemistry, serving as a sophisticated building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers targeting central nervous system (CNS) and other therapeutic areas.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial precursor in the multi-step synthesis of complex drug candidates, particularly those with spirocyclic motifs.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Development: Employed in the process development and scale-up stages for new chemical entities (NCEs), especially in neurological and psychiatric drug pipelines.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.
• Academic Research: Utilized in university and institutional labs for studying synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 7-Methoxy-3,4-Dihydro-2H-Spiro[Isoquinoline-1,4'-Piperidine]-1'-Carboxylate
CAS No.	1160247-66-4
Molecular Formula	C19H26N2O3
Molecular Weight	330.42 g/mol
Synonyms	1'-Boc-7-Methoxy-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-piperidine]; tert-Butyl 7-methoxy-3,4-dihydro-1'H-spiro[isoquinoline-1,4'-piperidine]-1'-carboxylate; 7-Methoxy-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1,2,3,4-Tetrahydro-7-methoxyspiro[isoquinoline-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Boc-7-Methoxy-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-piperidine]; 1160247-66-4; Spiro[isoquinoline-1,4'-piperidine]-1'-carboxylate derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Methoxy-3,4-Dihydro-2H-Spiro[Isoquinoline-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and regulatory documentation needs. We adhere to cGMP principles where applicable to ensure consistent batch-to-batch reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and away from incompatible materials. For long-term storage, consider under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.