Description

tert-Butyl 1-oxa-4,8-diazaspiro[5.5]undecane-4-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral research. It is essential for medicinal chemistry teams in pharmaceutical R&D and fine chemical manufacturing seeking to develop new therapeutic candidates with improved pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules targeting neurological disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• API Development: Serves as a core structural element in the development of new Active Pharmaceutical Ingredients (APIs), especially for protease inhibitors and receptor modulators.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring spirocyclic motifs.
• Process Chemistry: Acts as a starting material or intermediate in the scale-up and optimization of synthetic routes for clinical trial material production.

Basic Information

Product Name	tert-Butyl 1-oxa-4,8-diazaspiro[5.5]undecane-4-carboxylate
CAS No.	1160247-06-2
Molecular Formula	C13H24N2O3
Molecular Weight	256.34 g/mol
Synonyms	1-Oxa-4,8-diazaspiro[5.5]undecane-4-carboxylic acid, 1,1-dimethylethyl ester; 4-(tert-Butoxycarbonyl)-1-oxa-4,8-diazaspiro[5.5]undecane; tert-Butyl 1-oxa-4,8-diazaspiro[5.5]undecane-4-carboxylate; 1-Oxa-4,8-diazaspiro[5.5]undecane-4-carboxylic acid tert-butyl ester; Boc-1-oxa-4,8-diazaspiro[5.5]undecane; Spirocyclic amino ether Boc-protected intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-oxa-4,8-diazaspiro[5.5]undecane-4-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.