Description

n-[2-Trifluoroacetyl-4-Chloro-5-(Triisopropylsilyloxy)Phenyl]-2,2-Dimethylpropanamide is a high-value, advanced pharmaceutical intermediate characterized by its complex molecular architecture incorporating trifluoroacetyl, chloro, and triisopropylsilyloxy protecting groups. This compound matters as a critical building block in modern organic synthesis, enabling the development of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing sophisticated molecular targets.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective therapies.
• Agrochemical Research: Serves as a precursor for developing new-generation herbicides and fungicides, leveraging its halogenated and silyl-protected phenol moiety.
• Chemical Biology Probe Development: Used to create labeled or modified compounds for studying biological pathways and protein interactions.
• Material Science Precursor: Potential building block for specialty polymers and advanced organic electronic materials due to its robust amide linkage and aromatic system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, bespoke intermediates.

Basic Information

Item	Details
Product Name	n-[2-Trifluoroacetyl-4-Chloro-5-(Triisopropylsilyloxy)Phenyl]-2,2-Dimethylpropanamide
CAS No.	1159977-61-3
Molecular Formula	C22H33ClF3NO3Si
Molecular Weight	479.99 g/mol
Synonyms	2,2-Dimethyl-N-[2-(trifluoroacetyl)-4-chloro-5-[(triisopropylsilyl)oxy]phenyl]propanamide; N-(2-Trifluoroacetyl-4-chloro-5-triisopropylsilyloxyphenyl)pivalamide; 2,2-Dimethyl-N-(2-trifluoroacetyl-4-chloro-5-triisopropylsilyloxyphenyl)propanamide; TIPS-Protected Trifluoroacetyl Chlorophenol Pivalamide; 1159977-61-3; Advanced Pharma Intermediate 1159977-61-3; TIPS-CF3-Chloro-Pivalanilide Derivative
EINECS	Contact for details

Quality Control

Our n-[2-Trifluoroacetyl-4-Chloro-5-(Triisopropylsilyloxy)Phenyl]-2,2-Dimethylpropanamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific client requirements for pharmaceutical development (GMP standards) or research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.