Description

(4As,7As)-tert-Butyl 6-Tosylhexahydropyrrolo[3,4-B][1,4]Oxazine-4(4Ah)-Carboxylate CAS NO 1159908-22-1 is a high-purity, advanced pharmaceutical intermediate characterized by its complex fused bicyclic structure. This compound is of significant value in modern organic synthesis, particularly for constructing novel molecular scaffolds with precise stereochemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), especially within therapeutic areas requiring sophisticated heterocyclic chemistry.

Application

• Key Intermediate in Pharmaceutical R&D: Serves as a critical building block for the synthesis of complex drug candidates, particularly those targeting the central nervous system.
• Peptidomimetic Chemistry: Used in the design and synthesis of peptidomimetics and constrained peptides due to its pyrrolo-oxazine core.
• Ligand and Catalyst Development: Employed in academic and industrial research for creating novel chiral ligands or organocatalysts.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale production of high-value fine chemicals.
• Library Synthesis for Drug Discovery: A valuable scaffold for generating diverse compound libraries in high-throughput screening campaigns.

Basic Information

Product Name	(4As,7As)-tert-Butyl 6-Tosylhexahydropyrrolo[3,4-B][1,4]Oxazine-4(4Ah)-Carboxylate
CAS No.	1159908-22-1
Molecular Formula	C18H26N2O5S
Molecular Weight	382.48 g/mol
Synonyms	tert-Butyl (4aR,7aR)-6-(4-methylphenyl)sulfonyl-4a,5,6,7,7a,8-hexahydro-4H-pyrrolo[3,4-b][1,4]oxazine-4-carboxylate; (4aR,7aR)-N-Boc-6-tosyl-4a,5,6,7,7a,8-hexahydro-4H-pyrrolo[3,4-b][1,4]oxazine; (4aR,7aR)-tert-Butyl 6-tosyl-4a,5,6,7,7a,8-hexahydro-4H-pyrrolo[3,4-b][1,4]oxazine-4-carboxylate; (4aR,7aR)-6-(p-Toluenesulfonyl)hexahydropyrrolo[3,4-b][1,4]oxazine-4(4aH)-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Every batch of (4As,7As)-tert-Butyl 6-Tosylhexahydropyrrolo[3,4-B][1,4]Oxazine-4(4Ah)-Carboxylate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.