Description

tert-Butyl 6-Amino-3,4-Dihydroisoquinoline-2(1H)-Carboxylate Hydrochloride is a high-purity, protected amine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex nitrogen-containing heterocycles, essential in modern pharmaceutical research and development. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and oncology.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the isoquinoline core.
• Peptidomimetic Synthesis: Serves as a constrained scaffold to mimic peptide secondary structures, enhancing metabolic stability and bioavailability in drug design.
• Library Synthesis for High-Throughput Screening (HTS): Employed in the generation of diverse compound libraries due to its multiple points for derivatization.
• Agrochemical Active Ingredient Development: Used in the research phase for creating new herbicides, fungicides, or insecticides with novel modes of action.
• Chemical Biology Probe Development: Utilized to create tool compounds for studying enzyme function and biological pathways.

Basic Information

Product Name	tert-Butyl 6-Amino-3,4-Dihydroisoquinoline-2(1H)-Carboxylate Hydrochloride
CAS No.	1159822-30-6
Molecular Formula	C14H19N2O2·HCl
Molecular Weight	282.77 g/mol (Free base: 247.31 g/mol)
Synonyms	1,2,3,4-Tetrahydro-6-isoquinolinamine, 2-[(1,1-dimethylethoxy)carbonyl]-, hydrochloride (1:1); 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydro-6-isoquinolinamine hydrochloride; Boc-6-Amino-1,2,3,4-tetrahydroisoquinoline hydrochloride; N-Boc-6-Amino-THIQ hydrochloride; tert-Butyl 6-amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylate hydrochloride; 6-Amino-THIQ-Boc hydrochloride; 2-Boc-6-amino-1,2,3,4-tetrahydroisoquinoline HCl
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Amino-3,4-Dihydroisoquinoline-2(1H)-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.