Description

2-Bromo-4-(cyclobutyl)thiazole is a high-value, heterocyclic organic building block featuring a brominated thiazole core substituted with a cyclobutyl group. This compound is critical for medicinal chemistry and agrochemical research, serving as a versatile intermediate for the synthesis of novel active pharmaceutical ingredients (APIs) and crop protection agents. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific steric and electronic properties into their target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the thiazole moiety is a common bioactive scaffold.
• Material Science Research: Serves as a precursor for advanced organic materials, including ligands for catalysis and components for organic electronics.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic routes.
• Academic & Institutional Research: Used in university and government laboratories for fundamental studies in organic and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	2-Bromo-4-(cyclobutyl)thiazole
CAS No.	1159820-59-3
Molecular Formula	C7H8BrNS
Molecular Weight	218.11 g/mol
Synonyms	4-Cyclobutyl-2-bromothiazole; 2-Bromo-4-cyclobutyl-1,3-thiazole; 2-Bromo-4-cyclobutylthiazole; Thiazole, 2-bromo-4-cyclobutyl-; 1159820-59-3; AKOS026714023; ZINC000095049968
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-(cyclobutyl)thiazole is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for sensitive R&D and scale-up processes. A detailed Certificate of Analysis (COA) is supplied with each shipment, typically including results from HPLC, GC, NMR, and mass spectrometry analyses.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/GC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.