Description

8-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a versatile brominated isoquinolinone derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its value lies in providing a functionalized scaffold for constructing complex nitrogen-containing heterocycles, which are pivotal in modern drug discovery and materials science. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential therapeutic agents, including kinase inhibitors, CNS-active compounds, and anticancer candidates.
• Agrochemical Research: Used in developing novel pesticides and herbicides by acting as a core structure for bioactive molecule design.
• Organic Synthesis Reagent: Serves as a versatile electrophile or precursor for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex substituents.
• Material Science Precursor: Potential monomer or functional unit in the development of advanced organic electronic materials or specialty polymers.
• Academic & R&D: Essential tool compound in medicinal chemistry labs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	8-Bromo-3,4-dihydroisoquinolin-1(2H)-one
CAS No.	1159811-99-0
Molecular Formula	C9H8BrNO
Molecular Weight	226.07 g/mol
Synonyms	8-Bromo-1,2,3,4-tetrahydroisoquinolin-1-one; 8-Bromo-3,4-dihydro-1(2H)-isoquinolinone; 8-Bromo-1-oxo-1,2,3,4-tetrahydroisoquinoline; 8-Bromotetrahydroisoquinolin-1-one; 1159811-99-0; 8-Bromo-3,4-dihydroisoquinolin-1(2H)-one; 8-Bromo-1,2,3,4-tetrahydroisoquinoline-1-one
EINECS	Contact for details

Quality Control

Our 8-Bromo-3,4-dihydroisoquinolin-1(2H)-one is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our standard quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.