Description

3-(2-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinolin-6-Yl)Propanoic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected amine group and a carboxylic acid functional handle. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile building block for medicinal chemistry and drug discovery programs. It is primarily utilized by research institutions and pharmaceutical manufacturers developing novel therapeutic agents, particularly in the fields of central nervous system (CNS) and cardiovascular drug candidates.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Peptidomimetic Development: The tetrahydroisoquinoline core and propanoic acid moiety make it valuable for designing and synthesizing peptidomimetics and protease inhibitors.
• Building Block for Bioconjugation: The carboxylic acid group enables coupling reactions for labeling or attaching targeting ligands in prodrug and antibody-drug conjugate (ADC) research.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for the preparation of complex heterocyclic compounds and natural product analogs.

Basic Information

Product Name	3-(2-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinolin-6-Yl)Propanoic Acid
CAS No.	1158756-02-5
Molecular Formula	C17H23NO4
Molecular Weight	305.37 g/mol
Synonyms	6-[2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]propanoic acid; 3-[2-[(2-Methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinolin-6-yl]propanoic acid; Boc-THIQ-6-yl-propanoic Acid; N-Boc-6-(2-carboxyethyl)-1,2,3,4-tetrahydroisoquinoline; 3-(2-(Boc)-1,2,3,4-tetrahydroisoquinolin-6-yl)propionic acid
EINECS	Contact for details

Quality Control

Every batch of 3-(2-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinolin-6-Yl)Propanoic Acid is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with stringent industry standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.