Description

5-Iodo-3,3-Dimethyl-2,3-Dihydro-1H-Indole is a high-value, halogenated indoline derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring a reactive iodine atom on the aromatic ring, makes it an essential building block for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for neurological and oncological targets.
• Agrochemical Research: Building block for developing new pesticides and herbicides with specific modes of action.
• Material Science: Used in the creation of organic semiconductors, dyes, and photoactive materials.
• Cross-Coupling Reactions: Serves as a versatile electrophilic partner in palladium-catalyzed reactions (e.g., Suzuki, Heck, Sonogashira) for C-C bond formation.
• Chemical Biology: Useful for labeling and modifying biomolecules due to the reactivity of the iodine moiety.
• Ligand and Catalyst Development: Intermediate for synthesizing specialized ligands used in asymmetric catalysis.

Basic Information

Item	Details
Product Name	5-Iodo-3,3-Dimethyl-2,3-Dihydro-1H-Indole
CAS No.	1158745-57-3
Molecular Formula	C10H12IN
Molecular Weight	273.11 g/mol
Synonyms	5-Iodo-3,3-dimethylindoline; 3,3-Dimethyl-5-iodo-2,3-dihydro-1H-indole; 5-Iodo-3,3-dimethyl-1H-indole; 1H-Indole, 5-iodo-3,3-dimethyl-2,3-dihydro-; 3,3-Dimethyl-5-iodoindoline
EINECS	Contact for details

Quality Control

Our 5-Iodo-3,3-Dimethyl-2,3-Dihydro-1H-Indole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.