Description

S-3,3'-Bis(Triphenylsilyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2-Naphthyl Phosphate is a sophisticated chiral organophosphorus compound featuring bulky triphenylsilyl groups and a hydrogenated binaphthyl backbone. This compound is valued for its role as a highly effective chiral ligand or catalyst precursor in asymmetric synthesis, where it imparts exceptional stereoselectivity. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers developing advanced active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Asymmetric Catalysis: Serving as a key chiral ligand or catalyst in transition metal-catalyzed reactions such as hydrogenation, cross-coupling, and C-H functionalization.
• Pharmaceutical Intermediate Synthesis: Enabling the stereoselective construction of complex molecules for novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Chiral Auxiliary: Used to induce chirality in the synthesis of enantiomerically pure compounds for agrochemicals and advanced materials.
• Material Science Research: Potential application in the development of chiral polymers or frameworks with specific optical properties.
• Academic & Industrial R&D: A valuable tool for chemists exploring new methodologies in stereoselective organic synthesis.

Basic Information

Product Name	S-3,3'-Bis(Triphenylsilyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2-Naphthyl Phosphate
CAS No.	1157989-25-7
Molecular Formula	C62H56O4P2Si2
Molecular Weight	991.30 g/mol
Synonyms	(S)-3,3'-Bis(triphenylsilyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthyl phosphate; (S)-H8-BINOL-3,3'-diyl bis(triphenylsilyl) phosphate; S-BINOL-3,3'-bis(OTPS) phosphate; S-OctahydroBINOL bis(triphenylsilyl) phosphate; Chiral binaphthyl phosphate ligand; (S)-3,3'-Di-O-triphenylsilyl-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate
EINECS	Contact for details

Quality Control

Our production of S-3,3'-Bis(Triphenylsilyl)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2-Naphthyl Phosphate adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by NMR, HPLC, and chiral HPLC analysis to confirm identity, chemical purity, and enantiomeric excess (ee). A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment and handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.