Description

1-(5-Bromothiophene-3-Carbonyl)Piperidin-4-Ol is a high-purity, advanced pharmaceutical intermediate characterized by its distinct bromothiophene and piperidine-based structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new therapeutic agents or functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and lead optimization due to its modifiable bromo and hydroxyl functional groups.
• Agrochemical Research: Serves as a precursor in the synthesis of novel pesticides and herbicides, leveraging the thiophene moiety for biological activity.
• Chemical Biology Probe Development: Employed in the creation of molecular probes for studying enzyme function and biological pathways.
• Material Science Research: Potential precursor for organic electronic materials and conductive polymers due to the thiophene component.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of client-specific molecules.

Basic Information

Product Name	1-(5-Bromothiophene-3-Carbonyl)Piperidin-4-Ol
CAS No.	1156669-66-7
Molecular Formula	C10H12BrNO2S
Molecular Weight	290.18 g/mol
Synonyms	4-Hydroxy-1-(5-bromothiophene-3-carbonyl)piperidine; 1-(5-Bromo-3-thienylcarbonyl)-4-hydroxypiperidine; 4-Piperidinol, 1-[(5-bromo-3-thienyl)carbonyl]-; Piperidin-4-ol, 1-(5-bromothiophene-3-carbonyl)-; 5-Bromothiophene-3-carboxylic acid piperidin-4-yl ester (tautomeric form); 5-Bromo-3-thiophenecarboxylic acid 4-hydroxy-1-piperidinyl ester; BTP-OH intermediate
EINECS	Contact for details

Quality Control

Our production of 1-(5-Bromothiophene-3-Carbonyl)Piperidin-4-Ol adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. While typically supplied as a standard R&D grade, we can discuss custom synthesis under controlled conditions to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.