Description

5-Bromo-4,6-Difluoro-1H-Indole is a halogenated indole derivative serving as a versatile and high-value synthetic building block. Its molecular structure, featuring bromine and fluorine substituents at strategic positions, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides by incorporating the difluorinated indole scaffold.
• Material Science: Building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology: Serves as a probe or labeling agent in biochemical research to study protein interactions and enzyme mechanisms.
• Academic & Contract Research: Essential reagent for methodological development and discovery chemistry in university and CRO laboratories.

Basic Information

Product Name	5-Bromo-4,6-Difluoro-1H-Indole
CAS No.	1154742-51-4
Molecular Formula	C8H4BrF2N
Molecular Weight	232.03 g/mol
Synonyms	5-Bromo-4,6-difluoroindole; 4,6-Difluoro-5-bromo-1H-indole; 1H-Indole, 5-bromo-4,6-difluoro-; 5-Bromo-4,6-difluoro-1H-indole; 5-Br-4,6-F2-Indole
EINECS	Contact for details

Quality Control

Our 5-Bromo-4,6-Difluoro-1H-Indole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.