Description

Methyl 4-(Trifluoromethoxy)-1H-Indole-2-Carboxylate is a high-value, multi-functional indole derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its molecular structure, featuring both an indole core and a trifluoromethoxy group, makes it an essential building block for creating novel compounds with enhanced biological activity and physicochemical properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new agrochemicals, pharmaceuticals, and functional materials, where its unique scaffold enables the exploration of new chemical space.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used to develop new generations of herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve metabolic stability and bioavailability.
• Material Science: Serves as a monomer or functional additive in the research of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D.

Basic Information

Product Name	Methyl 4-(Trifluoromethoxy)-1H-Indole-2-Carboxylate
CAS No.	1154319-83-1
Molecular Formula	C11H8F3NO3
Molecular Weight	259.18 g/mol
Synonyms	Methyl 4-(trifluoromethoxy)-1H-indole-2-carboxylate; 1H-Indole-2-carboxylic acid, 4-(trifluoromethoxy)-, methyl ester; 4-(Trifluoromethoxy)indole-2-carboxylic acid methyl ester; Methyl 4-(trifluoromethoxy)indole-2-carboxylate; 1154319-83-1; MFCD30566633
EINECS	Contact for details

Quality Control

Our production of Methyl 4-(Trifluoromethoxy)-1H-Indole-2-Carboxylate adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC-MS, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound is light-sensitive and should be handled accordingly. Keep away from strong bases and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.