Description

5-Bromo-6-Chloro-1,3-Dihydro-2H-Indol-2-One is a high-purity, halogenated indolinone derivative serving as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a versatile, functionalized scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel therapeutic agents, especially within the fields of oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its modifiable indolinone core.
• Kinase Inhibitor Development: Serves as a privileged scaffold in the design and synthesis of potent and selective kinase inhibitors.
• Chemical Biology Probes: Utilized in the creation of tool compounds for investigating biological targets and signaling pathways.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Agrochemical Research: Potential intermediate in the development of new agrochemicals with novel modes of action.

Basic Information

Product Name	5-Bromo-6-Chloro-1,3-Dihydro-2H-Indol-2-One
CAS No.	1153885-37-0
Molecular Formula	C8H5BrClNO
Molecular Weight	246.49 g/mol
Synonyms	5-Bromo-6-chloroindolin-2-one; 2H-Indol-2-one, 5-bromo-6-chloro-1,3-dihydro-; 5-Bromo-6-chloro-1,3-dihydro-2H-indol-2-one; 6-Chloro-5-bromoindolin-2-one; 5-Bromo-6-chlorooxindole; 2-Oxo-5-bromo-6-chloroindoline
EINECS	Contact for details

Quality Control

Our 5-Bromo-6-Chloro-1,3-Dihydro-2H-Indol-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects requiring compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.