Description

5-Iodo-2-Methyl-2H-Indazole is a high-purity, halogenated indazole derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique molecular structure, which enables the introduction of both an iodine atom and a methylated indazole core into target molecules, facilitating the development of novel chemical entities. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and as a key intermediate in the synthesis of more complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A versatile scaffold for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery programs.
• Agrochemical Synthesis: Used as a precursor in the creation of novel herbicides, fungicides, and insecticides, leveraging its halogenated heterocyclic structure.
• Material Science Research: Employed in the synthesis of organic electronic materials, ligands for catalysis, and advanced polymers where its specific halogen and heterocycle properties are beneficial.
• Cross-Coupling Reactions: Serves as a key substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) due to the reactive iodine moiety.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Academic & Contract Research: A fundamental reagent for methodological development and exploratory synthesis in university and CRO laboratory settings.

Basic Information

Product Name	5-Iodo-2-Methyl-2H-Indazole
CAS No.	1150617-94-9
Molecular Formula	C8H7IN2
Molecular Weight	258.06 g/mol
Synonyms	2-Methyl-5-iodo-2H-indazole; 5-Iodo-2-methylindazole; 5-Iodo-2-methyl-1H-indazole; 1150617-94-9; 2H-Indazole, 5-iodo-2-methyl-; AI3-52375; SCHEMBL23346877; ZINC000253949777
EINECS	Contact for details

Quality Control

Every batch of 5-Iodo-2-Methyl-2H-Indazole is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard research-grade material typically meets a purity specification of ≥95% (HPLC). A detailed Certificate of Analysis (COA) providing batch-specific results for assay, related substances, and identification is available upon request. We support custom synthesis to meet specific purity requirements (e.g., ≥98% or ≥99%) for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to minimize exposure to moisture and atmospheric contaminants. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.