Description

1-Boc-4-(Ethoxycarbonyl)Indole-2-Boronic Acid is a high-purity, multi-functional boronic acid derivative designed for advanced organic synthesis. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex indole-based drug candidates, particularly for oncology and CNS-targeted therapies.
• Suzuki-Miyaura Cross-Coupling: Essential boron reagent for palladium-catalyzed carbon-carbon bond formation to create biaryl and heterobiaryl structures.
• Medicinal Chemistry Research: Used in library synthesis for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Material Science: Building block for creating organic electronic materials and advanced polymers with specific optoelectronic properties.
• Agrochemical Synthesis: Intermediate in the development of novel crop protection agents and herbicides.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and scale-up projects.

Basic Information

Product Name	1-Boc-4-(Ethoxycarbonyl)Indole-2-Boronic Acid
CAS No.	1150114-37-6
Molecular Formula	C₁₆H₂₀BNO₆
Molecular Weight	333.15 g/mol
Synonyms	1-Boc-4-(Ethoxycarbonyl)-1H-indole-2-boronic acid; 2-Borono-1-[(tert-butoxy)carbonyl]-1H-indole-4-carboxylic acid ethyl ester; tert-Butyl 4-(ethoxycarbonyl)-2-borono-1H-indole-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(ethoxycarbonyl)indole-2-boronic acid; 1-Boc-4-(COOEt)Indole-2-B(OH)₂; B-1-Boc-4-(ethoxycarbonyl)-1H-indol-2-ylboronic acid; 1H-Indole-4-carboxylic acid, 2-borono-1-[(1,1-dimethylethoxy)carbonyl]-, ethyl ester
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(Ethoxycarbonyl)Indole-2-Boronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥95% (by HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, supporting our clients' needs for regulatory filings in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.