Description

3-(2-Fluoropyridin-4-Yl)-1H-Indazol-5-Amine is a high-purity, advanced pharmaceutical intermediate featuring a unique indazole-pyridine hybrid scaffold. This compound is of significant commercial interest for its role as a critical building block in the research and development of novel, small-molecule therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in oncology, kinase inhibitor, and targeted drug discovery programs. The structural motif offers valuable synthetic handles for further functionalization, enabling the creation of diverse compound libraries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors and other biologically active molecules.
• Oncology Drug Discovery: Serves as a core scaffold for developing potential anti-cancer agents due to the indazole pharmacophore.
• Chemical Biology Research: Used in probe and tool compound development for studying enzyme function and cellular pathways.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies and lead optimization campaigns in drug discovery pipelines.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and niche APIs.
• Academic Research: Employed in university and institutional labs for novel heterocyclic chemistry and drug design projects.

Basic Information

Product Name	3-(2-Fluoropyridin-4-Yl)-1H-Indazol-5-Amine
CAS No.	1148142-15-7
Molecular Formula	C13H9FN4
Molecular Weight	240.24 g/mol
Synonyms	5-Amino-3-(2-fluoropyridin-4-yl)-1H-indazole; 3-(2-Fluoropyridin-4-yl)-1H-indazol-5-amine; 1H-Indazol-5-amine, 3-(2-fluoro-4-pyridinyl)-; 1148142-15-7; 3-(2-Fluoro-4-pyridinyl)-1H-indazol-5-amine; AKOS025147192; FT-0773665; BCP33213
EINECS	Contact for details

Quality Control

Our 3-(2-Fluoropyridin-4-Yl)-1H-Indazol-5-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.