Description

2-Chloro-4-(Ethynyl)Thiophene is a high-purity, specialized heterocyclic building block featuring both halogen and alkyne functional groups. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules in advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and organic electronics industries for constructing novel thiophene-based architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the creation of advanced crop protection agents and herbicides, leveraging the thiophene scaffold for bioactivity.
• Material Science & Organic Electronics: Serves as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Cross-Coupling Reactions: The ethynyl group enables Sonogashira couplings, while the chloro substituent is amenable to Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions for modular synthesis.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Acts as a versatile handle for click chemistry (via the alkyne) to label biomolecules or create fluorescent probes.

Basic Information

Product Name	2-Chloro-4-(Ethynyl)Thiophene
CAS No.	1148049-36-8
Molecular Formula	C6H3ClS
Molecular Weight	142.60 g/mol
Synonyms	4-Ethynyl-2-chlorothiophene; 2-Chloro-4-ethynylthiophene; 2-Chloro-4-thiopheneacetylene; Thiophene, 2-chloro-4-ethynyl-; 1148049-36-8
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Ethynyl)Thiophene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.