Description

1H-Pyrazole-1-Carboxylic Acid, 4-[1-(Phenylsulfonyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridin-5-Yl]-, 1,1-Dimethylethyl Ester is a sophisticated boronic ester derivative designed for advanced synthetic chemistry. This compound is a critical building block in modern pharmaceutical and agrochemical research, enabling precise carbon-carbon bond formation through cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for oncology, antiviral, and central nervous system (CNS) drug candidates.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronate ester coupling partner for constructing biaryl and heterobiaryl systems under mild conditions.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic frameworks.
• Material Science: Employed in the synthesis of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology & Proteomics: Acts as a functional handle for bioconjugation and the development of activity-based probes and inhibitors.
• Process Chemistry & Scale-Up: Provides a stable, crystalline alternative to boronic acids for robust and scalable manufacturing processes.

Basic Information

Product Name	1H-Pyrazole-1-Carboxylic Acid, 4-[1-(Phenylsulfonyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridin-5-Yl]-, 1,1-Dimethylethyl Ester
CAS No.	1147998-42-2
Molecular Formula	C28H31BN4O6S
Molecular Weight	562.44 g/mol
Synonyms	tert-Butyl 4-[1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-1H-pyrazole-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[1-(benzenesulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyrazole; 1H-Pyrrolo[2,3-b]pyridine Boronic Ester, N-Boc Protected; CAS 1147998-42-2; 1-Boc-4-[1-(PhSO2)-3-(PinB)-7-azaindol-5-yl]pyrazole
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrazole-1-Carboxylic Acid, 4-[1-(Phenylsulfonyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridin-5-Yl]-, 1,1-Dimethylethyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and LC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture uptake and decomposition. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (by NMR)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.