Description

3-Cyclopropyl-1H-Indazole CAS NO 1146395-69-8 is a high-purity, advanced pharmaceutical intermediate featuring a unique indazole core substituted with a cyclopropyl group. This specific molecular architecture makes it a critical building block in modern medicinal chemistry, particularly for the synthesis of novel bioactive compounds. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors and other potent drug candidates.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Used in the development of chemical probes for studying specific biological pathways and enzyme functions.
• Agrochemical Research: Potential intermediate for developing new active ingredients with specific biological activity.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for novel heterocyclic chemistry and synthetic methodology development.

Basic Information

Product Name	3-Cyclopropyl-1H-Indazole
CAS No.	1146395-69-8
Molecular Formula	C10H10N2
Molecular Weight	158.20 g/mol
Synonyms	3-Cyclopropyl-1H-indazole; 1H-Indazole, 3-cyclopropyl-; 3-Cyclopropylindazole; 3-CPI; Cyclopropanecarbonitrile, 2-(2-aminophenyl)-; 2-(2-Aminophenyl)cyclopropanecarbonitrile (precursor); 3-Cyclopropyl-1H-indazole-5-carboxylic acid (related derivative); 3-Cyclopropylindazol
EINECS	Contact for details

Quality Control

Our 3-Cyclopropyl-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support compliance with relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.