Description

4,5-Dimethyl-2-(1H-Tetrazol-1-yl)-3-thiophenecarboxylic acid (Saltdata: Free) is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure combining tetrazole and thiophene moieties. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily sought after by R&D laboratories and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with potential biological activity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those requiring a tetrazole bioisostere for carboxylate or other acidic groups.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery programs.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, or insecticides with specific modes of action.
• Ligand and Catalyst Development: Utilized in organometallic chemistry for creating novel ligands due to the coordinating properties of the tetrazole and carboxylic acid groups.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials or metal-organic frameworks (MOFs).
• Bioconjugation and Probe Synthesis: The carboxylic acid functionality allows for coupling to biomolecules, making it useful for creating diagnostic probes or chemical biology tools.

Basic Information

Product Name	4,5-Dimethyl-2-(1H-Tetrazol-1-yl)-3-thiophenecarboxylic Acid (Saltdata: Free)
CAS No.	1146299-25-3
Molecular Formula	C9H10N4O2S
Molecular Weight	238.27 g/mol
Synonyms	4,5-Dimethyl-2-(1H-tetrazol-1-yl)thiophene-3-carboxylic acid; 2-(1H-Tetrazol-1-yl)-4,5-dimethyl-3-thiophenecarboxylic acid; 3-Thiophenecarboxylic acid, 4,5-dimethyl-2-(1H-tetrazol-1-yl)-; 4,5-Dimethyl-2-(tetrazol-1-yl)thiophene-3-carboxylic acid; 1-(4,5-Dimethyl-3-carboxythiophen-2-yl)-1H-tetrazole; Free acid of 1146299-25-3; Tetrazole-thiophene carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our 4,5-Dimethyl-2-(1H-tetrazol-1-yl)-3-thiophenecarboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and should be handled in a manner that minimizes prolonged exposure to air and moisture to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.