Description

tert-Butyl 4-Amino-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, protected amine derivative serving as a critical synthetic intermediate in advanced organic chemistry. This compound matters because it provides a versatile and reactive scaffold for constructing complex nitrogen-containing heterocycles, which are foundational to modern drug discovery. Pharmaceutical R&D and fine chemical synthesis professionals need it for the efficient development of novel active pharmaceutical ingredients (APIs) and other biologically relevant molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel therapeutic agents, particularly those targeting central nervous system (CNS) disorders and other disease areas.
• Organic Synthesis Reagent: Used in multi-step synthesis for constructing complex isoquinoline and tetrahydroisoquinoline frameworks prevalent in medicinal chemistry.
• Protecting Group Chemistry: The tert-butyloxycarbonyl (Boc) group protects the amine functionality, allowing for selective reactions at other sites on the molecule during complex syntheses.
• Research & Development: Essential for academic and industrial research labs exploring new chemical entities and reaction pathways in heterocyclic chemistry.
• Precursor for Agrochemicals: Serves as a starting material for developing new crop protection agents and pesticides with specific biological activity.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and materials science applications.

Basic Information

Product Name	tert-Butyl 4-Amino-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	1145753-88-3
Molecular Formula	C₁₄H₂₀N₂O₂
Molecular Weight	248.32 g/mol
Synonyms	2(1H)-Isoquinolinecarboxylic acid, 4-amino-3,4-dihydro-, 1,1-dimethylethyl ester; 4-Amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 4-amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; Boc-4-Amino-1,2,3,4-tetrahydroisoquinoline; 4-Amino-THIQ-Boc; 2-Boc-4-amino-1,2,3,4-tetrahydroisoquinoline; 4-Amino-1,2,3,4-tetrahydroisoquinoline-2-Boc
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Amino-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical development. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.