Description

1-Methyl-n-{2-[(Thiophen-2-Ylcarbonyl)Amino]Ethyl}-1H-Indole-3-Carboxamide is a sophisticated heterocyclic organic compound featuring a unique molecular architecture combining indole and thiophene moieties. This structure makes it a valuable high-purity intermediate for advanced research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, especially those targeting neurological or oncological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its complex heterocyclic scaffold.
• Biochemical Tool Compound: Serves as a precursor or reference standard in the development of assays and probes for biological target validation.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to create more complex molecules for advanced material science applications.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and process development services for the life sciences industry.

Basic Information

Item	Details
Product Name	1-Methyl-n-{2-[(Thiophen-2-Ylcarbonyl)Amino]Ethyl}-1H-Indole-3-Carboxamide
CAS No.	1144454-31-8
Molecular Formula	C17H17N3O2S
Molecular Weight	327.40 g/mol
Synonyms	1-Methyl-N-[2-[(thiophene-2-carbonyl)amino]ethyl]-1H-indole-3-carboxamide; 1-Methyl-1H-indole-3-carboxylic acid [2-[(thiophene-2-carbonyl)amino]ethyl]amide; N-(2-((1-Methyl-1H-indole-3-carboxamido)ethyl)thiophene-2-carboxamide; 1144454-31-8; Thiophene-indole carboxamide derivative
EINECS	Contact for details

Quality Control

Our production of 1-Methyl-n-{2-[(Thiophen-2-Ylcarbonyl)Amino]Ethyl}-1H-Indole-3-Carboxamide adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents are provided and available upon request. Our quality system supports compliance with cGMP and ISO standards where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider conditions under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.