Description

2-Methyl-1,4-Naphthalenediol-D8 is a deuterium-labeled analog of 2-Methyl-1,4-naphthalenediol, a key intermediate in the synthesis of vitamin K and related compounds. This high-purity, isotopically labeled compound is essential for advanced analytical and research applications where precise molecular tracking is required. It is primarily utilized by pharmaceutical researchers, analytical chemists, and manufacturers of reference standards in drug metabolism, pharmacokinetic studies, and mass spectrometry.

Application

• Internal Standard for Mass Spectrometry: Serves as a critical internal standard in LC-MS/MS and GC-MS analyses for the quantification of vitamin K analogs and their metabolites.
• Pharmaceutical Research: Used as a labeled precursor or intermediate in the research and development of novel pharmaceutical compounds, particularly those related to blood coagulation and bone metabolism.
• Metabolic Pathway Tracing: Enables detailed studies of drug metabolism and biochemical pathways due to its deuterium labeling, providing insights into absorption, distribution, metabolism, and excretion (ADME).
• Reference Standard Production: Employed by certified reference material (CRM) manufacturers to produce high-accuracy calibration standards for regulatory and quality control laboratories.
• Chemical Synthesis: Acts as a specialized building block in the synthesis of deuterated analogs of more complex molecules for research purposes.

Basic Information

Product Name	2-Methyl-1,4-Naphthalenediol-D8
CAS No.	1142409-65-1
Molecular Formula	C₁₁H₄D₈O₂
Molecular Weight	190.25 g/mol
Synonyms	2-Methyl-1,4-naphthalenediol-d8; 2-Methyl-1,4-dihydroxynaphthalene-d8; 2-Methylnaphthalene-1,4-diol-d8; 1,4-Dihydroxy-2-methylnaphthalene-d8; Deuteronated 2-Methyl-1,4-Naphthalenediol; Vitamin K Intermediate-d8; Menadiol Precursor-d8; Deuterated 2-Methyl-1,4-Naphthoquinone Diol
EINECS	Contact for details

Quality Control

Our 2-Methyl-1,4-Naphthalenediol-D8 is manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (Atom % D), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to cGMP principles for research chemicals, and specifications can be tailored to meet the rigorous demands of method development and regulatory submission support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.