Description

(4E)-3-(Chloromethyl)-4-[(5-Methyl-2-Thienyl)Methylene]Isoxazol-5(4H)-One is a specialized heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, featuring a reactive isoxazolone ring fused with chloromethyl and thienyl substituents, making it a versatile precursor for constructing complex pharmacophores. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

This advanced chemical intermediate is designed for high-value synthesis applications, particularly in research and development.

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders or possessing anti-inflammatory properties.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science Precursor: Potential use in the synthesis of organic semiconductors or functional polymers due to its conjugated system and reactive sites.
• Chemical Biology Probe: Can be utilized to create molecular probes for studying enzyme interactions or biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	(4E)-3-(Chloromethyl)-4-[(5-Methyl-2-Thienyl)Methylene]Isoxazol-5(4H)-One
CAS No.	1142199-93-6
Molecular Formula	C10H8ClNO2S
Molecular Weight	241.69 g/mol
Synonyms	3-(Chloromethyl)-4-[(5-methyl-2-thienyl)methylene]-2-isoxazolin-5-one; 4-[(5-Methyl-2-thienyl)methylene]-3-(chloromethyl)isoxazol-5(4H)-one; (4E)-3-(Chloromethyl)-4-(5-methylthiophen-2-ylmethylene)isoxazol-5(4H)-one; 5(4H)-Isoxazolone, 3-(chloromethyl)-4-[(5-methyl-2-thienyl)methylene]-, (4E)-; Building Block 1142199-93-6
EINECS	Contact for details

Quality Control

Our production of (4E)-3-(Chloromethyl)-4-[(5-Methyl-2-Thienyl)Methylene]Isoxazol-5(4H)-One adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your critical R&D and scale-up processes. Each lot undergoes comprehensive analytical characterization using techniques such as HPLC, GC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with relevant guidelines for investigational products.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, it is recommended to keep the material at 2-8°C under an inert atmosphere. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.