Description

(4E)-3-(Chloromethyl)-4-(1H-Indol-3-Ylmethylene)Isoxazol-5(4H)-One is a high-value synthetic organic intermediate featuring a unique molecular scaffold combining isoxazolone and indole moieties. This compound is critical for research and development in advanced pharmaceutical chemistry, enabling the synthesis of novel bioactive molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex heterocyclic libraries and targeted active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key building block for the synthesis of potential drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Research: Used in developing novel fungicides or herbicides by leveraging its reactive chloromethyl and isoxazolone groups.
• Chemical Biology Probe Development: Acts as a core structure for creating molecular probes to study enzyme inhibition or protein-ligand interactions.
• Material Science Precursor: Potential use in synthesizing specialized organic compounds for advanced material applications.
• Academic & Institutional R&D: Employed in universities and research institutes for methodological studies in heterocyclic and medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring complex, multi-functional intermediates.

Basic Information

Item	Details
Product Name	(4E)-3-(Chloromethyl)-4-(1H-Indol-3-Ylmethylene)Isoxazol-5(4H)-One
CAS No.	1142199-56-1
Molecular Formula	C14H9ClN2O2
Molecular Weight	272.69 g/mol
Synonyms	3-(Chloromethyl)-4-[(1H-indol-3-yl)methylene]-2-isoxazolin-5-one; (4E)-3-(Chloromethyl)-4-(1H-indol-3-ylmethylene)isoxazol-5(4H)-one; 4-[(1H-Indol-3-yl)methylene]-3-(chloromethyl)-4,5-dihydro-1,2-oxazol-5-one; 3-(Chloromethyl)-4-(indol-3-ylmethylene)isoxazol-5(4H)-one; Isoxazol-5(4H)-one, 3-(chloromethyl)-4-[(1H-indol-3-yl)methylene]-, (4E)-; CAS 1142199-56-1
EINECS	Contact for details

Quality Control

Every batch of (4E)-3-(Chloromethyl)-4-(1H-Indol-3-Ylmethylene)Isoxazol-5(4H)-One is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.