Description

4-Bromo-2-Cyclobutylthiazole is a high-value, halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a reactive bromo substituent and the unique steric and electronic profile of the cyclobutyl group, enabling precise molecular construction. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Agrochemical Research: Used to construct novel herbicide and pesticide scaffolds, leveraging the thiazole ring's bioactivity and the cyclobutyl moiety for enhanced binding properties.
• Material Science: Serves as a monomer or functional unit in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Ligand Synthesis: Utilized for creating novel nitrogen-sulfur (N,S) bidentate ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology: Employed as a molecular probe or tag in medicinal chemistry to study protein-ligand interactions and enzyme inhibition.

Basic Information

Product Name	4-Bromo-2-Cyclobutylthiazole
CAS No.	1142196-22-2
Molecular Formula	C7H8BrNS
Molecular Weight	218.11 g/mol
Synonyms	2-Cyclobutyl-4-bromothiazole; 4-Bromo-2-cyclobutyl-1,3-thiazole; Thiazole, 4-bromo-2-cyclobutyl-; 1142196-22-2; 4-Bromo-2-cyclobutylthiazole; 2-Cyclobutylthiazole, 4-bromo derivative; 4-Bromocyclobutylthiazole
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-Cyclobutylthiazole is manufactured and analyzed under strict quality management protocols to ensure consistency and reliability for your critical research and development projects. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. Our quality systems are designed to support cGMP and ISO standards for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.