Description

Etravirine-D6 is a deuterated isotopologue of the non-nucleoside reverse transcriptase inhibitor (NNRTI) Etravirine, specifically labeled with six deuterium atoms. This compound serves as a critical internal standard for the precise quantification of Etravirine in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is an essential tool for pharmaceutical R&D and clinical laboratories focused on antiretroviral drug development, bioanalytical method validation, and pharmacokinetic studies, ensuring data accuracy and regulatory compliance.

Application

• Bioanalytical Reference Standard: Primary use as an internal standard for the accurate quantification of Etravirine in plasma, serum, and other biological fluids via mass spectrometry.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development & Validation: Critical for developing and validating robust, GLP-compliant analytical methods in contract research organizations (CROs) and QA/QC labs.
• Drug Impurity Profiling: Used in stability studies and impurity identification to support drug substance and product characterization.
• Forensic & Clinical Toxicology: Supports accurate measurement in therapeutic drug monitoring (TDM) and forensic investigations.

Basic Information

Product Name	Etravirine-D6
CAS No.	1142096-06-7
Molecular Formula	C20H9D6BrN6O
Molecular Weight	447.33 g/mol
Synonyms	4-[[6-Amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile-d6; TMC125-D6; Intelence-D6; (4-[[6-Amino-5-bromo-2-[(4-cyanophenyl)amino]pyrimidin-4-yl]oxy]-3,5-dimethylphenyl)carbonitrile-d6; Deuterated Etravirine; Etravirine (hexadeuterated); R165335-D6
EINECS	Contact for details

Quality Control

Every batch of Etravirine-D6 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support your regulatory filings, including detailed Certificates of Analysis (COA) with batch-specific results for identity, purity (by HPLC), and isotopic enrichment. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and bioanalytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.