Description

1-(Tetrahydro-2H-Pyran-2-Yl)-3-(Trifluoromethyl)-1H-Pyrazol-5-Ylboronic Acid is a high-purity boronic acid derivative and a critical building block in modern synthetic organic chemistry. Its value lies in its role as a versatile intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is essential for R&D and production teams in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in the discovery and development of novel drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, ligands, and functional polymers.
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura cross-coupling to form carbon-carbon bonds, a fundamental transformation in medicinal and process chemistry.
• Chemical Biology & Proteomics: Can be utilized in the synthesis of molecular probes and inhibitors for biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for bespoke synthesis projects requiring specific boronic acid functionalities.

Basic Information

Product Name	1-(Tetrahydro-2H-Pyran-2-Yl)-3-(Trifluoromethyl)-1H-Pyrazol-5-Ylboronic Acid
CAS No.	1141878-45-6
Molecular Formula	C9H10BF3N2O3
Molecular Weight	262.00 g/mol
Synonyms	[3-(Trifluoromethyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl]boronic Acid; 1-(Tetrahydro-2H-pyran-2-yl)-3-(trifluoromethyl)-1H-pyrazol-5-ylboronic Acid; 3-Trifluoromethyl-1-tetrahydropyran-2-yl-1H-pyrazol-5-ylboronic Acid; 5-Borono-3-(trifluoromethyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole; THP-Protected 3-Trifluoromethylpyrazolylboronic Acid; 1-THP-3-CF3-Pyrazol-5-Boronic Acid; CAS 1141878-45-6
EINECS	Contact for details

Quality Control

Our 1-(Tetrahydro-2H-Pyran-2-Yl)-3-(Trifluoromethyl)-1H-Pyrazol-5-Ylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting standards for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Assay (NMR)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.