Description

4-Chloro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is a high-purity, advanced pharmaceutical intermediate with a protected indazole core structure. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile scaffold for medicinal chemistry research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and production of novel therapeutic agents, particularly in oncology and CNS drug development pipelines.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted small-molecule drugs and investigational new chemical entities (NCEs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Used in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs), especially those containing functionalized indazole motifs.
• Chemical Biology Probes: Employed in the development of chemical probes for studying enzyme function and biological pathways.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis and scale-up projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for novel heterocyclic chemistry and methodology development.

Basic Information

Product Name	4-Chloro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole
CAS No.	1137278-45-5
Molecular Formula	C₁₂H₁₃ClN₂O
Molecular Weight	236.70 g/mol
Synonyms	4-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; 4-Chloro-1-(tetrahydropyran-2-yl)-1H-indazole; 4-Chloro-1-(THP)-1H-indazole; 1H-Indazole, 4-chloro-1-(tetrahydro-2H-pyran-2-yl)-; 4-Chloro-1-(oxan-2-yl)-1H-indazole; 4-Chloro-1-(2-tetrahydropyranyl)-1H-indazole; 1137278-45-5; 4-Cl-1-THP-indazole
EINECS	Contact for details

Quality Control

Our 4-Chloro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for trace metals, residual solvents, and related substances, supporting development from research to commercial scale under ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.