Description

7-Hydroxy Coumarin Sulfate is a chemically modified derivative of the naturally occurring coumarin scaffold, specifically the sulfate ester of 7-hydroxycoumarin (umbelliferone). This compound is of significant interest in advanced chemical synthesis and life science research due to its role as a key synthetic intermediate and a model substrate for studying sulfate conjugation, a critical metabolic pathway. It is primarily utilized by research institutions and industrial R&D departments focused on pharmaceutical development, analytical chemistry, and the synthesis of novel fluorophores or bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of more complex drug candidates and prodrugs, particularly those requiring sulfate ester functionalities for enhanced solubility or targeted delivery.
• Biochemical Research: Used as a standard or probe substrate in enzymatic assays to study the activity of sulfotransferase enzymes, which are vital in drug metabolism and detoxification processes.
• Fluorescent Probe Development: Acts as a core structure for developing new fluorescent dyes and sensors, leveraging the inherent photophysical properties of the coumarin moiety.
• Analytical Reference Standard: Employed as a high-purity reference material in HPLC, LC-MS, and other analytical methods for method development, validation, and quality control in pharmaceutical and contract research organizations.
• Organic Synthesis: Utilized in organic chemistry research for exploring novel sulfate esterification reactions and creating libraries of derivatives for structure-activity relationship (SAR) studies.
• Cosmetic & Personal Care Ingredient Research: Investigated for potential applications in the development of new active ingredients where the sulfate group modifies bioavailability or skin penetration.

Basic Information

Product Name	7-Hydroxy Coumarin Sulfate
CAS No.	1135316-80-1
Molecular Formula	C9H6O6S
Molecular Weight	242.21 g/mol
Synonyms	Umbelliferone sulfate; 7-Hydroxy-2H-chromen-2-one sulfate; 7-Hydroxycoumarin hydrogen sulfate; Coumarin-7-yl sulfate; 2-Oxo-2H-chromen-7-yl hydrogen sulfate; 7-(Sulfooxy)-2H-chromen-2-one
EINECS	Contact for details

Quality Control

Our 7-Hydroxy Coumarin Sulfate is produced and controlled under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.