Description

([Ring-D5]Phe3)-Octreotide CAS NO 1134880-79-7 is a deuterium-labeled analog of the therapeutic peptide octreotide, where five hydrogen atoms on the phenylalanine-3 aromatic ring are replaced with deuterium. This stable isotope-labeled compound is critical for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in mass spectrometry-based assays. It is primarily utilized by pharmaceutical research laboratories, contract research organizations (CROs), and academic institutions engaged in pharmacokinetic studies, drug metabolism research, and the development of robust LC-MS/MS assays for octreotide and its derivatives.

Application

• Internal Standard for LC-MS/MS Quantification: Essential for the accurate and precise measurement of octreotide concentrations in complex biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables reliable tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Serves as a critical component in establishing FDA/EMA-compliant analytical methods for therapeutic drug monitoring and regulatory submissions.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry experiments.
• Quality Control in Pharmaceutical Manufacturing: Can be used in analytical procedures to ensure the consistency and purity of octreotide active pharmaceutical ingredient (API) and finished drug products.

Basic Information

Product Name	([Ring-D5]Phe3)-Octreotide
CAS No.	1134880-79-7
Molecular Formula	C49H61D5N10O10S2
Molecular Weight	1019.3 g/mol (for major isotope)
Synonyms	Deuterated Octreotide (Phe3-D5); Octreotide (Phe3-[ring-D5]); D5-Octreotide; SMS 201-995 (Phe3-D5); Sandostatin Internal Standard (D5); (D-Phe-Cys-Phe([ring-D5])-D-Trp-Lys-Thr-Cys)-Thr-ol (cyclic 2-7 disulfide); LANREOTIDE Related Compound D (deuterated variant).
EINECS	Contact for details

Quality Control

Our deuterated peptide standards are manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive mass spectrometry applications. Each batch is characterized by advanced analytical techniques including HPLC, MS, and NMR to confirm identity, purity, and deuterium incorporation. Certificates of Analysis (COA) are provided, detailing assay purity (typically ≥95% by HPLC), isotopic purity (≥98 atom % D), and analytical data. We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Isotopic Purity (Atom % D)	≥ 98%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.