Description

Buprenorphine-D9 is a deuterated internal standard of the opioid partial agonist buprenorphine, specifically designed for analytical applications. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analysis in complex matrices. It is primarily used by analytical chemists and researchers in pharmaceutical development, forensic toxicology, and clinical research laboratories for precise drug quantification and metabolism studies.

Application

• Primary use as an internal standard for the accurate quantification of buprenorphine in biological samples via LC-MS/MS and GC-MS.
• Critical component in forensic analysis and drug testing protocols to ensure reliable and legally defensible results.
• Supporting pharmacokinetic and metabolism studies in pharmaceutical R&D by tracking drug distribution and clearance.
• Calibration and method validation in clinical research and therapeutic drug monitoring (TDM) programs.
• Quality control and reference standard in the manufacturing of analytical kits and reagents for diagnostic use.
• Use in environmental and wastewater analysis to detect and quantify pharmaceutical residues.

Basic Information

Product Name	Buprenorphine-D9
CAS No.	1134630-65-1
Molecular Formula	C29H32D9NO4
Molecular Weight	469.7 g/mol (approx.)
Synonyms	Buprenorphine-d9; 21-Cyclopropyl-7α-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine-d9; Deuterated Buprenorphine; Buprenorphine (phenyl-d9); Buprenorphine Internal Standard; Bup-d9; BPN-d9
EINECS	Contact for details

Quality Control

Every batch of Buprenorphine-D9 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, with comprehensive testing including assay, isotopic purity (D-enrichment), and identification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (LC-MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.