Description

5-[[4-[1,1,2,2-Tetradeuterio-2-(5-Ethylpyridin-2-Yl)Ethoxy]Phenyl]Methyl]-1,3-Thiazolidine-2,4-Dione is a deuterated analog of a thiazolidinedione derivative, serving as a critical stable isotope-labeled reference standard and synthetic intermediate. This compound is essential for metabolic and pharmacokinetic studies, providing enhanced analytical precision in mass spectrometry. It is primarily required by pharmaceutical R&D and contract research organizations for the development and validation of novel therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a certified internal standard for the quantitative bioanalysis of its non-deuterated parent drug and metabolites via LC-MS/MS.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for conducting mass balance, absorption, distribution, metabolism, and excretion (ADME) studies in preclinical and clinical research.
• Isotope Dilution Mass Spectrometry (IDMS): Enables highly accurate and precise quantification in complex biological matrices, improving data reliability.
• Synthetic Intermediate: Employed in the research-scale synthesis of other deuterium-labeled compounds for mechanistic and tracer studies.
• Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants during drug substance development.
• Regulatory Submissions: Supports the generation of data packages required for regulatory filings with agencies like the FDA and EMA.

Basic Information

Product Name	5-[[4-[1,1,2,2-Tetradeuterio-2-(5-Ethylpyridin-2-Yl)Ethoxy]Phenyl]Methyl]-1,3-Thiazolidine-2,4-Dione
CAS No.	1134163-31-7
Molecular Formula	C19H17D4N2O3S
Molecular Weight	369.48 g/mol
Synonyms	5-[[4-[1,1,2,2-Tetradeutero-2-(5-ethyl-2-pyridyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione; Deuterated Thiazolidinedione Derivative; [D4]-Labeled TZD Intermediate; 5-[(4-{[1,1,2,2-2H4]-2-(5-Ethylpyridin-2-yl)ethoxy}benzyl)-1,3-thiazolidine-2,4-dione; 1134163-31-7; (2,4-Dioxo-1,3-thiazolidin-5-yl)methylphenyl deuterated ether; Deuterium-labeled PPARγ ligand intermediate.
EINECS	Contact for details

Quality Control

This high-value reference material is produced under strict quality control protocols. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm isotopic enrichment, chemical purity, and identity. Certificates of Analysis (COA) are provided, detailing batch-specific results for assay, isotopic purity, and related substances. Our quality system is designed to meet the stringent requirements of pharmaceutical R&D and analytical laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is moisture-sensitive (hygroscopic); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.