Description

Pioglitazone-D4 is a high-purity, deuterium-labeled analog of the thiazolidinedione-class pharmaceutical compound Pioglitazone. This stable isotope-labeled material is essential for conducting precise and reliable quantitative bioanalytical studies, particularly in drug metabolism and pharmacokinetics (DMPK) research. It serves as a critical internal standard for scientists and quality control laboratories in the pharmaceutical, contract research organization (CRO), and academic sectors, ensuring accurate mass spectrometry analysis and supporting regulatory submissions.

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for bioanalysis.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking and quantification of Pioglitazone and its metabolites in biological matrices (plasma, serum, urine).
• Clinical Research and Bioequivalence Testing: Supports high-quality data generation in clinical trials for generic drug development and regulatory compliance.
• Pharmaceutical Quality Control: Used in analytical method development and validation within pharmaceutical manufacturing QC labs.
• Forensic and Anti-Doping Analysis: Facilitates precise detection and quantification in specialized analytical testing protocols.
• Stable Isotope Labeling Research: Serves as a tool in mechanistic studies of metabolic pathways and enzymatic processes.

Basic Information

Product Name	Pioglitazone-D4
CAS No.	1134163-29-3
Molecular Formula	C₁₉H₁₆D₄N₂O₃S
Molecular Weight	360.46 g/mol
Synonyms	5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione-d4; (±)-Pioglitazone-d4; Pioglitazone (deuterated); Pioglitazone D4; U-72107A-d4; AD-4833-d4; ACTOS-d4 (deuterated analog); 5-{4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl}-2,4-thiazolidinedione-d4
EINECS	Contact for details

Quality Control

Every batch of Pioglitazone-D4 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and isotopic enrichment meet the exacting standards required for analytical research. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results for assay, isotopic purity, and related substances by validated methods such as HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.