Description

Bazedoxifene-D4 Acetate is a high-purity, deuterated internal standard critical for advanced analytical quantification in pharmaceutical research and development. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of mass spectrometry-based bioanalytical methods, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic laboratories focused on women's health and selective estrogen receptor modulator (SERM) therapeutics.

Application

• Primary use as an internal standard for the precise quantification of Bazedoxifene and its metabolites in biological matrices via LC-MS/MS and GC-MS.
• Critical component in pharmacokinetic (PK) and bioequivalence studies to determine drug absorption, distribution, metabolism, and excretion (ADME) profiles.
• Enhances data accuracy in clinical trial sample analysis for drug development programs targeting osteoporosis and other estrogen-related conditions.
• Supports forensic and anti-doping analysis requiring definitive identification and measurement of SERM compounds.
• Used in metabolite identification and profiling studies to understand drug degradation pathways.
• Facilitates method development and validation in analytical laboratories to meet FDA, EMA, and ICH guidelines.
• Applied in stable isotope dilution assays to achieve superior precision and accuracy over conventional calibration methods.

Basic Information

Product Name	Bazedoxifene-D4 Acetate
CAS No.	1133695-49-4
Molecular Formula	C32H34D4N2O5
Molecular Weight	530.67 g/mol
Synonyms	Bazedoxifene-d4 Acetate; 1-[[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol-d4 Acetate; TSE-424-d4 Acetate; WAY-140424-d4 Acetate; Conbriza-d4 (deuterated); (7-Methoxy-2-(4-methoxyphenyl)-3-methyl-4H-chromen-4-one)-d4 Acetate (related structure); Deuterated Bazedoxifene Acetate; Bazedoxifene (D4) Acetate
EINECS	Contact for details

Quality Control

Every batch of our Bazedoxifene-D4 Acetate is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity to meet the exacting standards of analytical applications. Comprehensive testing includes identity confirmation, assay, isotopic enrichment (D4), and control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with our rigorous specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, ideally between 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.