Description

Vildagliptin D7 CAS NO 1133208-42-0 is a high-purity, deuterium-labeled internal standard essential for accurate quantitative analysis in pharmaceutical research and development. This stable isotope-labeled compound is critical for ensuring the precision and reliability of bioanalytical methods, particularly Liquid Chromatography-Mass Spectrometry (LC-MS/MS). It is primarily used by analytical chemists and researchers in pharmaceutical companies and contract research organizations (CROs) for pharmacokinetic studies, drug metabolism research, and quality control of the antidiabetic drug vildagliptin.

Application

• Bioanalytical Method Development and Validation: Serves as a critical internal standard for quantifying vildagliptin and its metabolites in biological matrices (plasma, serum, urine) using LC-MS/MS.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables precise measurement of drug concentration over time to determine absorption, distribution, metabolism, and excretion (ADME) profiles.
• Drug Metabolism Studies: Used in metabolite identification and quantification to understand the biotransformation pathways of vildagliptin.
• Clinical Trial Support: Provides essential data integrity for bioanalysis in human clinical trials, ensuring regulatory compliance for submissions to agencies like the FDA and EMA.
• Quality Control and Impurity Profiling: Acts as a reference standard in the quality control of vildagliptin active pharmaceutical ingredient (API) and finished dosage forms.
• Doping Control Analysis: Potential application in sports anti-doping laboratories for the precise detection of vildagliptin.

Basic Information

Item	Details
Product Name	Vildagliptin D7
CAS No.	1133208-42-0
Molecular Formula	C17H18D7N3O2
Molecular Weight	306.43 g/mol (for D7 labeled form)
Synonyms	LAF237 D7; (2S)-1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-pyrrolidinecarbonitrile D7; NVP-LAF-237 D7; Galvus D7 (labeled); 1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine D7; Vildagliptin-d7; Deuterated Vildagliptin; Vildagliptin (D7, 98%)
EINECS	Contact for details

Quality Control

Every batch of Vildagliptin D7 is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to ensure it meets the exacting standards required for use as an internal standard in regulated bioanalysis. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters including chemical purity, isotopic purity (D-enrichment), and chromatographic purity as determined by advanced techniques like NMR and HPLC/MS. Our quality commitment supports compliance with GMP/GLP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.