Description

o-T-Butyldimethylsilyl3-Bromo-4-Methoxyphenol is a high-purity, protected phenolic intermediate designed for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise functional group manipulation in complex molecule construction. It is primarily utilized in the pharmaceutical and agrochemical industries for the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those requiring brominated aromatic systems with protected hydroxyl groups.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the bromo-methoxy phenol moiety is a critical structural feature.
• Organic Synthesis Reagent: Serves as a versatile intermediate in academic and industrial research for cross-coupling reactions, such as Suzuki or Stille couplings, facilitated by the bromine atom.
• Material Science Precursor: Employed in the development of specialty polymers and advanced organic materials that incorporate halogenated phenolic units.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group provides a stable protection for the phenol, allowing for selective reactions elsewhere on the molecule in multi-step syntheses.

Basic Information

Product Name	o-T-Butyldimethylsilyl3-Bromo-4-Methoxyphenol
CAS No.	1133116-37-6
Molecular Formula	C₁₃H₂₁BrO₂Si
Molecular Weight	317.30 g/mol
Synonyms	3-Bromo-4-methoxyphenol tert-butyldimethylsilyl ether; 3-Bromo-4-methoxyphenyl tert-butyldimethylsilyl ether; TBDMS ether of 3-Bromo-4-methoxyphenol; 2-Bromo-4-[(tert-butyldimethylsilyl)oxy]anisole; (3-Bromo-4-methoxyphenoxy)(tert-butyl)dimethylsilane; tert-Butyl(3-bromo-4-methoxyphenoxy)dimethylsilane; 3-Br-4-MeO-PhO-TBDMS
EINECS	Contact for details

Quality Control

Our o-T-Butyldimethylsilyl3-Bromo-4-Methoxyphenol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity and purity, meeting the stringent requirements for synthetic intermediates. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.