Description

tert-Butyl 3-[1-Methyl-3-(4-Benzyl-2-Oxo-1,3-Oxazolidin-3-Yl)-3-Oxopropyl]Indole-1-Carboxylate is a sophisticated indole-based building block and chiral auxiliary of significant interest in advanced organic synthesis. Its value lies in its complex molecular architecture, which incorporates both a protected indole nitrogen and a chiral oxazolidinone moiety, making it a critical intermediate for constructing stereochemically defined molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for complex targets requiring high enantiomeric purity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or reagent in stereoselective reactions to induce enantioselectivity in the formation of new carbon-carbon or carbon-heteroatom bonds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for discovering new bioactive indole derivatives.
• Process Chemistry Development: Used in scaling up synthetic routes for potential APIs, where its defined stereochemistry is crucial for reproducibility and regulatory filing.
• Academic Research: A valuable compound for methodological studies in organic chemistry, particularly in exploring new catalytic or auxiliary-controlled transformations.

Basic Information

Product Name	tert-Butyl 3-[1-Methyl-3-(4-Benzyl-2-Oxo-1,3-Oxazolidin-3-Yl)-3-Oxopropyl]Indole-1-Carboxylate
CAS No.	1132816-77-3
Molecular Formula	C27H30N2O5
Molecular Weight	462.54 g/mol
Synonyms	1-Boc-3-[1-methyl-3-(4-benzyl-2-oxo-1,3-oxazolidin-3-yl)-3-oxopropyl]indole; tert-Butyl 3-(1-methyl-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)propyl)-1H-indole-1-carboxylate; 1H-Indole-1-carboxylic acid, 3-[1-methyl-3-[(4-benzyl-2-oxo-3-oxazolidinyl)carbonyl]propyl]-, 1,1-dimethylethyl ester; (S)-tert-Butyl 3-(1-methyl-3-(4-benzyl-2-oxooxazolidine-3-carbonyl)propyl)indole-1-carboxylate; tert-Butyl 3-(1-methyl-3-(4-benzyl-2-oxooxazolidine-3-carbonyl)propyl)-1H-indole-1-carboxylate; BOC-protected indole oxazolidinone derivative; 1132816-77-3.
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-[1-Methyl-3-(4-Benzyl-2-Oxo-1,3-Oxazolidin-3-Yl)-3-Oxopropyl]Indole-1-Carboxylate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. Each lot undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be sensitive to moisture and should be handled under inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.