Description

N'-Hydroxy-n-(2,3,4,5,6-Pentadeuteriophenyl)Octanediamide is a deuterated chemical compound, specifically a deuterium-labeled derivative of a hydroxamic acid derivative, with the CAS registry number 1132749-48-4. This compound is of significant value as a stable isotope-labeled internal standard or tracer in advanced analytical and research applications, ensuring superior accuracy and reliability in quantitative analysis. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in metabolism studies, pharmacokinetic research, and method development using mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Used as a high-purity, isotopically labeled internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise quantification of its non-deuterated counterpart in complex biological matrices.
• Metabolite Tracing & Pharmacokinetics: Enables accurate tracking of drug metabolism, absorption, distribution, and excretion (ADME) studies in preclinical and clinical research.
• Biomarker Research: Facilitates the development and validation of sensitive analytical assays for biomarker discovery and validation.
• Proteomics & Chemical Biology: Serves as a specialized tool in chemical proteomics for studying enzyme inhibition, particularly those involving hydroxamate-based mechanisms, such as histone deacetylases (HDACs).
• Reference Material: Acts as a certified reference material (CRM) for calibrating analytical instruments and ensuring regulatory compliance in data submission.
• Organic Synthesis Intermediate: Utilized as a building block in the synthesis of more complex deuterated molecules for research purposes.

Basic Information

Item	Details
Product Name	N'-Hydroxy-n-(2,3,4,5,6-Pentadeuteriophenyl)Octanediamide
CAS No.	1132749-48-4
Molecular Formula	C₁₄H₁₃D₅N₂O₃
Molecular Weight	279.34 g/mol (for deuterated form)
Synonyms	N-Hydroxy-N'-(2,3,4,5,6-pentadeuteriophenyl)octanediamide; Pentadeutero-Suberanilic Hydroxamic Acid; [D5]-SAHA analogue; Deuterated Vorinostat analogue; Octanediamide, N-hydroxy-N-(2,3,4,5,6-pentadeuteriophenyl)-; Isotope Labeled HDAC Inhibitor; 1132749-48-4; [phenyl-D5]-N-Hydroxyoctanediamide
EINECS	Contact for details

Quality Control

Every batch of N'-Hydroxy-n-(2,3,4,5,6-Pentadeuteriophenyl)Octanediamide is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, typically exceeding 98% (by HPLC) and 99 atom % D, respectively, to meet the exacting demands of analytical science. Comprehensive Certificates of Analysis (COA) are provided, detailing results for identity, purity, isotopic abundance, and residual solvents. Our quality commitment aligns with the standards expected for research-grade and GMP-starting materials.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.