Description

4-Hydroxy-1-(3-Pyridyl-2,4,5,6-D4)-1-Butanone is a deuterium-labeled derivative of a key pyridyl butanone intermediate, offering a stable isotopic label for advanced research and analytical applications. This compound is critical for studies requiring precise metabolic tracing, pharmacokinetic analysis, and the development of sensitive detection methods. It is primarily utilized by pharmaceutical researchers, analytical chemists, and contract research organizations (CROs) engaged in drug discovery and development.

Application

• As a stable isotopic internal standard for the quantitative analysis of its non-deuterated counterpart in complex biological matrices using LC-MS/MS.
• In metabolic pathway studies and drug metabolism and pharmacokinetics (DMPK) research to track the fate of pharmaceutical compounds.
• For use in deuterium labeling chemistry to synthesize more complex labeled molecules for mechanistic studies.
• As a high-purity reference material in analytical method development and validation to ensure accuracy and regulatory compliance.
• In academic and industrial research focusing on nicotinic receptor-related pathways or the synthesis of novel chemical entities.

Basic Information

Product Name	4-Hydroxy-1-(3-Pyridyl-2,4,5,6-D4)-1-Butanone
CAS No.	1132666-98-8
Molecular Formula	C9H7D4NO2
Molecular Weight	169.21 g/mol
Synonyms	4-Hydroxy-1-(3-pyridinyl-2,4,5,6-d4)-1-butanone; 1-(Pyridin-3-yl-2,4,5,6-d4)-4-hydroxybutan-1-one; Deuterated 4-Hydroxy-1-(3-pyridyl)-1-butanone; 3-Pyridyl-d4-4-hydroxybutanone; 4-Hydroxy-1-(3-pyridyl-d4)-1-butanone; Stable Isotope Labeled Nicotine Metabolite Reference Standard
EINECS	Contact for details

Quality Control

Every batch of 4-Hydroxy-1-(3-Pyridyl-2,4,5,6-D4)-1-Butanone is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet exacting standards. Our quality commitment includes traceable documentation and adherence to cGMP principles where applicable. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC/NMR), isotopic purity (by MS), and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container sealed to protect the deuterium label integrity and prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.